Intraretinal pigmented cells in retinal degenerative disease.

Marina YasvoinaQian YangSasha M WoodsTjebo HeerenGrant M ComerCatherine A EganMarcus Fruttiger

Published in: The British journal of ophthalmology (2022)

Our findings suggest that RPE cells invading the retina dedifferentiate (losing classic RPE markers) and can be pigmented or unpigmented. Therefore, the number of RPE cells invading the retina in retinal degenerative disease may be underappreciated by funduscopy.

Keyphrases

induced apoptosis
cell cycle arrest
diabetic retinopathy
optical coherence tomography
endoplasmic reticulum stress
optic nerve
signaling pathway
cell death
cell proliferation
pi k akt