Alteration of Inflammatory Mediators in the Upper and Lower Airways under Chronic Intermittent Hypoxia: Preliminary Animal Study.

Eun Jung LeeWoon HeoJoo Young KimHyungchul KimMin Jung KangBo Ra KimJi Hyun KimDo Yang ParkChang-Hoon KimJoo-Heon YoonHyung-Ju Cho

Published in: Mediators of inflammation (2017)

CIH for 4 weeks altered the levels of inflammatory mediators in both the nose and lungs of mouse model. We suggest that the airway immune system may be deteriorated by CIH and allergic inflammation in the upper or lower airway could be worsened by sleep apnea.

Keyphrases

sleep apnea
oxidative stress
mouse model
positive airway pressure
obstructive sleep apnea
cystic fibrosis
endothelial cells
high intensity