Genetic Regulation of Cytokine Response in Patients with Acute Community-Acquired Pneumonia.

Andreas KühnapfelKatrin HornUlrike KlotzMichael KiehntopfMaciej RosolowskiMarkus LoefflerPeter AhnertNorbert SuttorpMartin Witzenrath Markus Scholz

Published in: Genes (2022)

This is the first context-specific genetic association study of blood cytokine concentrations in CAP patients revealing numerous biologically plausible candidate genes. Two of the loci were also associated with atherosclerosis with probable common or consecutive pathomechanisms.

Keyphrases

genome wide
community acquired pneumonia
end stage renal disease
ejection fraction
newly diagnosed
chronic kidney disease
cardiovascular disease
copy number
peritoneal dialysis
gene expression
patient reported outcomes