Inhibition of HSP90 S-nitrosylation alleviates cardiac fibrosis via TGFβ/SMAD3 signalling pathway.

Xiyue ZhangYihua ZhangQing MiaoZhiguang ShiLulu HuShangmin LiuJie GaoShuang ZhaoHongshan ChenZhengrong HuangYi HanYong Ji Li-Ping Xie

Published in: British journal of pharmacology (2021)

Genetic or pharmacological inhibition of SNO-HSP90 mitigates fibrosis through blocking the TGFβ/SMAD3 signalling pathway, providing a potential therapy for cardiac remodelling.

Keyphrases

transforming growth factor
epithelial mesenchymal transition
heat shock protein
heat shock
left ventricular
heat stress
genome wide
mouse model
copy number
dna methylation
radiation therapy