Determining the Relationship Between Blood Pressure, Kidney Function, and Chronic Kidney Disease: Insights From Genetic Epidemiology.

Natalie Staplin William G Herrington Federico MurgiaMaysson IbrahimKatherine R BullParminder K JudgeSarah Y A NgMichael TurnerDoreen ZhuJonathan R EmbersonMartin J LandrayColin BaigentRichard HaynesJemma C Hopewell

Published in: Hypertension (Dallas, Tex. : 1979) (2022)

In this general population, genetic epidemiological evidence supports a causal role of life-long differences in BP for decreased kidney function, glomerular hyperfiltration, and albuminuria. Physiological autoregulation may not afford complete renal protection against the moderate BP elevations.

Keyphrases

chronic kidney disease
blood pressure
genome wide
end stage renal disease
copy number
risk factors
high intensity
hypertensive patients
heart rate
type diabetes
dna methylation
gene expression
weight loss