Pleiotropic effects of an eQTL in the CELSR2/PSRC1/SORT1 cluster that associates with LDL-C and resting metabolic rate.

Khushdeep BandeshKendrick FreelandMichael TraurigRobert L HansonClifton BogardusPaolo Piaggi Leslie J Baier

Published in: The Journal of clinical endocrinology and metabolism (2024)

Variants in the CELSR2/PSRC1/SORT1 locus exhibit tissue-specific effects on metabolic traits, with an independent role in muscle metabolism through glucocorticoid signaling.

Keyphrases

skeletal muscle
heart rate
copy number
heart rate variability
genome wide
genome wide association study