MicroRNA-17-5p Reduces Inflammation and Bone Erosions in Mice With Collagen-Induced Arthritis and Directly Targets the JAK/STAT Pathway in Rheumatoid Arthritis Fibroblast-like Synoviocytes.
Aurélie NajmFrançois-Marie MassonPauline PreussSteven GeorgesBenjamin OryThibaut QuillardShatakshi SoodCarl S GoodyearDouglas J VealeUrsula FearonBenoit Le GoffFrédéric BlanchardPublished in: Arthritis & rheumatology (Hoboken, N.J.) (2020)
We demonstrate an antiinflammatory and antierosive role of miR-17 in vivo. This effect involves the suppression of the IL-6 family autocrine-amplifying loop through the direct targeting of JAK1 and STAT3.
Keyphrases
- rheumatoid arthritis
- cell proliferation
- oxidative stress
- diabetic rats
- long non coding rna
- disease activity
- high glucose
- high fat diet induced
- bone mineral density
- wound healing
- cancer therapy
- ankylosing spondylitis
- long noncoding rna
- interstitial lung disease
- transcription factor
- type diabetes
- adipose tissue
- metabolic syndrome
- bone regeneration
- bone loss
- drug delivery
- systemic lupus erythematosus
- wild type
- insulin resistance
- body composition
- systemic sclerosis