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Site-Selective Electrochemical Oxidation of Glycosides.

Marios KidonakisAugustin VillotetMartin D WitteSebastian B BeilAdriaan J Minnaard
Published in: ACS catalysis (2023)
Quinuclidine-mediated electrochemical oxidation of glycopyranosides provides C3-ketosaccharides with high selectivity and good yields. The method is a versatile alternative to Pd-catalyzed or photochemical oxidation and is complementary to the 2,2,6,6-tetramethylpiperidine 1-oxyl (TEMPO)-mediated C6-selective oxidation. Contrary to the electrochemical oxidation of methylene and methine groups, the reaction proceeds without oxygen.
Keyphrases
  • electron transfer
  • hydrogen peroxide
  • gold nanoparticles
  • ionic liquid
  • molecularly imprinted
  • room temperature
  • mass spectrometry
  • solid phase extraction
  • tandem mass spectrometry
  • structural basis