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Convenient exosome separation by phosphatidylserine targeting polymer brush materials.

Shuming LiShasha HaoYetong YangYuxing HeChenle LongZhi-Qi ZhangJing Zhang
Published in: Chemical communications (Cambridge, England) (2023)
We report phosphatidylserine targeting polymer brush materials to selectively separate exosomes. This method provides an efficient separation strategy with ordinary centrifuge force, which improves the integrity and purity of the exosomes. Compared with the common methods, the content of contaminated lipoprotein in the resulting exosomes decreased obviously.
Keyphrases
  • mesenchymal stem cells
  • stem cells
  • cancer therapy
  • liquid chromatography
  • heavy metals
  • bone marrow
  • single molecule
  • risk assessment
  • mass spectrometry
  • drug delivery