Lactonase Activity, Status, and Genetic Variations of Paraoxonase 1 in Women with Gestational Diabetes Mellitus.

Mi ZhouXing-Hui LiuQing-Qing LiuMeng ChenHuai BaiLin-Bo GuanPing Fan

Published in: Journal of diabetes research (2020)

The lactonase activities of PON1 are increased in women with GDM. PON1 genetic variants, increased oxidative stress, and abnormalities in lipoproteins may be associated with these changes.PON1 genetic variants and oxidative stress indices in Chinese women with GDM.

Keyphrases

oxidative stress
dna damage
diabetic rats
ischemia reperfusion injury
pregnant women
induced apoptosis
genome wide
copy number
gene expression
signaling pathway