Rhodium-Catalyzed [7 + 1] Cycloaddition of Exocyclic 1,3-Dienylcyclopropanes and Carbon Monoxide.

Zhiqiang HuangXin WangYi JinZuwei WangZhi-Xiang Yu

Published in: Organic letters (2023)

A rhodium-catalyzed [7 + 1] reaction of exocyclic 1,3-dienylcyclopropanes and carbon monoxide has been developed to synthesize eight-membered carbocycle-embedded bicyclic and tricyclic molecules. In addition, ab initio calculations were conducted to reveal the reaction mechanism.

Keyphrases

room temperature
density functional theory
molecular dynamics
molecular dynamics simulations
genome wide
single cell
electron transfer
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monte carlo