Insulin growth factor-1 correlates with higher bone mineral density and lower inflammation status in obese adult subjects.
Rachele FornariChiara MaroccoDavide FrancomanoSimona FittipaldiCarla LubranoViviana M BimonteLorenzo M DoniniEmanuele NicolaiAntonio AversaAndrea LenziEmanuela A GrecoSilvia MigliaccioPublished in: Eating and weight disorders : EWD (2017)
In conclusion, our results show that higher levels of serum IGF-1 in obese patients correlate with lower inflammatory pattern and better skeletal health, as demonstrated by higher BMD and osteocalcin levels. These results lead to speculate the existence of a bone-adipose-muscle interplay modulating energy homeostasis, glucose, bone metabolism, and chronic inflammation in individuals affected by abdominal obesity.
Keyphrases
- bone mineral density
- obese patients
- growth factor
- postmenopausal women
- bariatric surgery
- oxidative stress
- type diabetes
- weight loss
- body composition
- gastric bypass
- metabolic syndrome
- insulin resistance
- roux en y gastric bypass
- adipose tissue
- healthcare
- public health
- signaling pathway
- mental health
- glycemic control
- health information
- blood glucose
- cell proliferation
- social media
- soft tissue
- childhood cancer
- young adults