Neonatal abstinence syndrome is a potential cause of low TREC copy number.
Adil AdatiaLing LingPranesh ChakrabortyLauren BrickRae BragerPublished in: Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology (2021)
Severe combined immunodeficiency (SCID) is a rare genetic condition characterized by significant T cell lymphopenia and impaired T cell function. Many jurisdictions use the quantitation of T cell receptor excision circles (TRECs) to screen for SCID in newborns, but false positives may be seen in several conditions. We report 3 newborns with neonatal abstinence syndrome who presented with decreased TREC copy number.
Keyphrases
- copy number
- mitochondrial dna
- genome wide
- pregnant women
- dna methylation
- smoking cessation
- case report
- low birth weight
- gestational age
- mass spectrometry
- cord blood
- ms ms
- high throughput
- early onset
- liquid chromatography tandem mass spectrometry
- gene expression
- preterm infants
- liquid chromatography
- simultaneous determination