Lock out SIRT4.

Published in: eLife (2024)

The accumulation of SIRT4 in the nuclei of kidney cells drives kidney fibrosis, so blocking the movement of this protein could be a potential therapeutic strategy against fibrosis.

Keyphrases

induced apoptosis
oxidative stress
ischemia reperfusion injury

cell cycle arrest
endoplasmic reticulum stress
liver fibrosis

protein protein
cell death

amino acid
binding protein