Maternal overnutrition by hypercaloric diets programs hypothalamic mitochondrial fusion and metabolic dysfunction in rat male offspring.

Robbi E Cardenas-PerezLizeth Fuentes-MeraAna Laura de la GarzaIvan Torre-VillalvazoLuis A Reyes-CastroHumberto Rodriguez-RochaAracely Garcia-GarciaJuan Carlos Corona-CastilloArmando R TovarElena ZambranoRocio Ortiz-LopezJennifer SavilleMaria FullerAlberto Camacho

Published in: Nutrition & metabolism (2018)

We concluded that maternal programming by HFD induces hypothalamic mitochondria fusion, metabolic dysfunction and fat accumulation in male offspring, which is exacerbated by HFD or CAF exposure after weaning, potentially due to mitochondria calcium overflux.

Keyphrases

high fat diet
oxidative stress
adipose tissue
insulin resistance
birth weight
cell death
pregnancy outcomes
reactive oxygen species
endoplasmic reticulum
mechanical ventilation
public health
weight loss
type diabetes
gestational age
pregnant women
metabolic syndrome