Epiregulin promotes hair growth via EGFR-medicated epidermal and ErbB4-mediated dermal stimulation.

Nahyun Choi Won-Serk Kim Sang Ho Oh Jong-Hyuk Sung

Published in: Cell proliferation (2020)

EREG, which is released from ORS cells, activated EGFR and ErbB4 on epidermal cells and DPCs during hair cycling, respectively. As a result, EREG stimulated epidermal cells a positive feedback and DPCs via regulating ROS generation for hair growth. Therefore, EREG therapy may be a novel solution for hair loss treatment.

Keyphrases

induced apoptosis
cell cycle arrest
tyrosine kinase
small cell lung cancer
epidermal growth factor receptor
cell death
endoplasmic reticulum stress
stem cells
signaling pathway
mesenchymal stem cells
high intensity
combination therapy