Computer-aided analysis of quercetin mechanism of overcoming docetaxel resistance in docetaxel-resistant prostate cancer.
Victor OmoboyedeOchapa IbrahimHaruna Isiyaku UmarGrace Ayomide OkeOlugbenga Samson OnileProsper Obed ChukwuemekaPublished in: Journal, genetic engineering & biotechnology (2023)
Further analysis revealed epidermal growth factor receptor (EGFR) as the most pertinent target of quercetin in reversing DR in DRPC, while molecular docking simulation revealed an effective interaction between quercetin and EGFR. Ultimately, this study provides a scientific rationale for the further exploration of quercetin as a combinational therapy with docetaxel.
Keyphrases
- epidermal growth factor receptor
- molecular docking
- tyrosine kinase
- prostate cancer
- advanced non small cell lung cancer
- small cell lung cancer
- locally advanced
- single cell
- molecular dynamics simulations
- clinical trial
- radical prostatectomy
- radiation therapy
- rectal cancer
- squamous cell carcinoma
- bone marrow
- replacement therapy