Mitochondrial fumarate promotes ischemia/reperfusion-induced tubular injury.

Zuo-Lin LiMing-Min HuangMeng-Yao YuDi-Fei NieSha-Li FuJing-Jing DiTing LanBi-Cheng LiuQiu-Li Wu

Published in: Acta physiologica (Oxford, England) (2024)

Our studies demonstrated that the mitochondrial-derived fumarate promotes tubular epithelial cell injury in renal I/RI. Blockade of fumarate-mediated ROS/NF-κB signaling activation may serve as a novel therapeutic approach to ameliorate hypoxic tubule injury.

Keyphrases

oxidative stress
high glucose
diabetic rats
dna damage
cell death
lps induced
immune response
pi k akt
nuclear factor
drug induced
inflammatory response