Three new nonenes from culture broth of marine-derived fungus Albifimbria verrucaria and their cytotoxic and anti-viral activities.
Young-Hee KimDae-Cheol ChoiDae-Won KiYeong-Seon WonSeung-Jae LeeJi-Yul KimIn-Kyoung LeeBong-Sik YunPublished in: The Journal of antibiotics (2024)
Three new nonenes, verrucanonenes A‒C (1‒3), were isolated from culture broth of marine-derived fungus Albifimbria verrucaria. These compounds were isolated using silica gel column chromatography, reversed-phase medium pressure liquid chromatography, Sephadex LH-20 column chromatography, and preparative HPLC. Their structures were determined using a spectroscopic method. Cytotoxicities of these isolated compounds to A549, DU145, HCT116, and HT1080 cancer cell lines were assessed. Compounds 1‒3 exhibited cytotoxicities to DU145 cancer cell line, with IC 50 values of 23.4, 28.6, and 20.1 µM, respectively. Compound 2 decreased H1N1-induced cytopathic effects on MDCK cells in a dose-dependent manner.
Keyphrases
- liquid chromatography
- mass spectrometry
- tandem mass spectrometry
- high resolution mass spectrometry
- simultaneous determination
- papillary thyroid
- high performance liquid chromatography
- solid phase extraction
- squamous cell
- high resolution
- induced apoptosis
- cell cycle arrest
- gas chromatography
- high speed
- ms ms
- sars cov
- high glucose
- diabetic rats
- lymph node metastasis
- squamous cell carcinoma
- drug induced
- cell death
- signaling pathway
- childhood cancer
- stress induced
- molecular dynamics simulations