Novel Alternatively Spliced Variants of Smad4 Expressed in TGF-β-Induced EMT Regulating Proliferation and Migration of A549 Cells.

Rongxue WanXichao XuLunkun MaYing ChenLiling Tang Jian-Guo Feng

Published in: OncoTargets and therapy (2020)

Our results indicated that novel Smad4 variants were expressed in TGF-β-induced EMT process. The functional study showed that these novel variants regulate cell proliferation and migration and affect E-cad and VIM protein expression, showing the potential as targets for cancer therapy.

Keyphrases

epithelial mesenchymal transition
transforming growth factor
copy number
cancer therapy
high glucose
diabetic rats
induced apoptosis
coronary artery disease
drug delivery
drug induced
stem cells
endothelial cells
cell therapy
risk assessment
genome wide
mesenchymal stem cells
bone marrow