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American Society of Hematology 2021 guidelines for sickle cell disease: stem cell transplantation.

Julie KanterRobert I LiemFrançoise BernaudinJavier Bolaños-MeadeCourtney D FitzhughJane Silva HankinsM Hassan MuradJulie A PanepintoDamiano RondelliShalini ShenoyJohn WagnerMark C WaltersTeonna WoolfordJoerg Johannes MeerpohlJohn F Tisdale
Published in: Blood advances (2021)
The evidence review yielded no randomized controlled clinical trials for HSCT in SCD; therefore, all recommendations are based on very low certainty in the evidence. Key recommendations include considering HSCT for those with neurologic injury or recurrent acute chest syndrome at an early age and to improve nonmyeloablative regimens. Future research should include the development of a robust SCD registry to serve as a comparator for HSCT studies.
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