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Gramicidin S-inspired antimicrobial cyclodextrin to disrupt gram-negative and gram-positive bacterial membranes.

Hatsuo YamamuraKana IsshikiYusuke FujitaHisato KatoTakashi KatsuKazufumi MasudaKayo OsawaAtsushi Miyagawa
Published in: MedChemComm (2019)
A membrane-active antimicrobial peptide gramicidin S-like amphiphilic structure was prepared from cyclodextrin. The mimic was a cyclic oligomer composed of 6-amino-modified glucose 2,3-di-O-propanoates and it exhibited antimicrobial activity against Gram-positive and Gram-negative bacteria, together with no resistance development and low haemolytic activity against red blood cells.
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