Warfarin, but not rivaroxaban, promotes the calcification of the aortic valve in ApoE-/- mice.
Marcello RattazziElisabetta FagginElisa BertaccoChiara NardinLeopoldo PaglianiMario PlebaniFrancesco CinettoDiego GuidolinMassimo PuatoPaolo PaulettoPublished in: Cardiovascular therapeutics (2018)
We showed that warfarin, but not rivaroxaban, could induce calcific valve degeneration in a mouse model of atherosclerosis. Both the treatments did not significantly affect the progression of atherosclerosis. Overall, these data suggest a safer profile of rivaroxaban on the risk of cardiovascular disease progression.
Keyphrases
- aortic valve
- atrial fibrillation
- venous thromboembolism
- direct oral anticoagulants
- transcatheter aortic valve replacement
- mouse model
- aortic stenosis
- transcatheter aortic valve implantation
- aortic valve replacement
- oral anticoagulants
- cardiovascular disease
- pulmonary embolism
- heart failure
- chronic kidney disease
- big data
- cognitive decline
- electronic health record
- mitral valve
- high fat diet induced
- machine learning
- data analysis
- wild type