Potential value of urine lateral-flow lipoarabinomannan (LAM) test for diagnosing tuberculosis among severely acute malnourished children.
Birgit SchrammRodrigue C NganaboyPiex UwiragiyeDidier MukebaAboubacar AbdoubaraIlla AbdouJean-Claude NshimiymanaSeyni SounnaLaurent HifflerLaurence FlevaudHelena HuergaPublished in: PloS one (2021)
These findings suggest the potential utility of LAM urine testing in HIV-negative children with SAM. Determine LAM-positivity with Grades >1 may identify HIV-negative SAM children that are eligible for rapid TB-treatment initiation, though low-intensity (Grade 1) LAM-positive results may not be helpful in this way. Further studies in this specific pediatric population are warranted, including evaluations of new generation LAM tests.
Keyphrases
- young adults
- antiretroviral therapy
- hiv infected
- hiv aids
- hiv positive
- human immunodeficiency virus
- hepatitis c virus
- mycobacterium tuberculosis
- hiv testing
- men who have sex with men
- respiratory failure
- hepatitis b virus
- pulmonary tuberculosis
- aortic dissection
- adverse drug
- sensitive detection
- loop mediated isothermal amplification