Novel role of STAT3 in microglia-dependent neuroinflammation after experimental subarachnoid haemorrhage.
Zhiyuan Vera ZhengJunfan ChenHao LyuSin Yu Erica LamGang LuWai Yee ChanKwok Chu George WongPublished in: Stroke and vascular neurology (2021)
STAT3 is closely related to the microglial polarisation transition and modulation of microglia-dependent neuroinflammation. Microglial STAT3 deletion improved neurological function and neuronal survival probably through promoting M2 polarisation and anti-inflammatory responses after SAH. STAT3 may serve as a promising therapeutic target to alleviate early brain injury after SAH.