Genetic polymorphisms in PXR and NF-κB1 influence susceptibility to anti-tuberculosis drug-induced liver injury.

Jingwei ZhangZhenzhen ZhaoHao BaiMinjin WangLin JiaoWu PengTao WuTangyuheng LiuHao ChenXingbo SongLijuan WuXuejiao HuQian WuJuan ZhouJiajia SongMengyuan LyvBinwu Ying

Published in: PloS one (2019)

Our study is the first to reveal that rs3814055 variants in PXR and rs78872571 and rs4647992 variants in NF-κB1 are associated with susceptibility to ATDILI caused by first-line anti-tuberculosis combination treatment in the Han Chinese population.

Keyphrases

signaling pathway
mycobacterium tuberculosis
lps induced
copy number
pi k akt
oxidative stress
pulmonary tuberculosis
nuclear factor
adverse drug
single cell
immune response
gene expression
hepatitis c virus
hiv infected
electronic health record