Intermittent Hypoxia-Induced Cardiomyocyte Death Is Mediated by HIF-1 Dependent MAM Disruption.
Sophie MoulinAmandine ThomasStefan WagnerMichael ArztHervé DubouchaudFrédéric LamarcheSophie BouyonGuillaume VialDiane Godin-RibuotJean Louis PépinClaire ArnaudElise BelaidiPublished in: Antioxidants (Basel, Switzerland) (2022)
IH-induced ER stress, MAM alterations and mitochondrial dysfunction were mediated by HIF-1; all these intermediate mechanisms ultimately inducing cardiomyocyte apoptosis. This suggests that HIF-1 modulation might limit the deleterious cardiac effects of SDB.