Mast cells participate in allograft rejection: can IL-37 play an inhibitory role?
Pio ContiAlessandro CaraffaGianpaolo RonconiSpiros K KritasFiliberto MastrangeloLucia TettamantiIlias FrydasTheoharis C TheoharidesPublished in: Inflammation research : official journal of the European Histamine Research Society ... [et al.] (2018)
IL-37 inhibition offers the opportunity to immunologically modulate MCs, by suppressing their production of IL-1 family members and reducing the risk of allograft rejection, resulting as a potential good therapeutic new cytokine. Here, we report the relationship between inflammatory MCs, allograft rejection and pro-inflammatory and anti-inflammatory IL-37.