Understanding the Complexation of Alkyl-Substituted Nitrilotriacetamides with Uranium: A Study by Absorption Spectroscopy and Microcalorimetry.

Complexation thermodynamics of UO 2 2+ ions with a series of alkyl-substituted nitrilotriacetamides (NTA) was investigated by absorption spectroscopy and microcalorimetry. The hexamethyl derivative of NTA (HMNTA) forms the weakest two successive complexes with UO 2 2+ ions with stability constants of log β 11 = 3.5 ± 0.1 and log β 12 = 6.1 ± 0.1. The formation constant values increased linearly with increasing alkyl chain length of the substituents from hexamethyl NTA to hexabutyl NTA (HBNTA) and to hexahexyl NTA (HHNTA). The complexation with each ligand was both enthalpy and entropy driven with exothermic enthalpy changes of Δ H 11 = -14.7 ± 1.0 kJ/mol, Δ H 12 = -10.2 ± 0.8 kJ/mol for HMNTA, Δ H 11 = -19.2 ± 1.2 kJ/mol, Δ H 12 = -16.4 ± 1.1 kJ/mol for HBNTA, and Δ H 11 = -21.3 ± 1.4 kJ/mol, Δ H 12 = -19.4 ± 2.3 kJ/mol for HHNTA. Similarly, the positive entropy changes with each ligand were Δ S 11 = 18.1 ± 2.7 J/mol/K, Δ S 12 = 82.9 ± 3.8 J/mol/K for HMNTA, Δ S 11 = 14.4 ± 1.2 J/mol/K, Δ S 12 = 87.2 ± 4.2 J/mol/K for HBNTA, and Δ S 11 = 16.1 ± 2.4 J/mol/K, Δ S 12 = 92.6 ± 3.1 J/mol/K for HHNTA. Structural features of the complex suggest the participation of two ligands coordinating in a bidentate mode via the carbonyl oxygens. The [UO 2 L 2 ] 2+ complexes appear to be noncentrosymmetric with two ligands and one water molecule occupying the equatorial plane of the dioxo uranyl cation. The structure of the complex was confirmed by 1 H NMR titration, EXAFS measurements, and DFT calculations.