Added value of patient- and drug-related factors to stratify drug-drug interaction alerts for risk of QT prolongation: Development and validation of a risk prediction model.
Katoo M MuylleSven van LaereLuigi PannoneSamuel CoenenCarlo de AsmundisAlain G DupontPieter CornuPublished in: British journal of clinical pharmacology (2022)
The prediction model including patient- and drug-related factors outperformed QT alerting based on QT-DDI severity alone and therefore is a promising strategy to improve DDI alerting.