Expression of expanded GGC repeats within NOTCH2NLC causes cardiac dysfunction in mouse models.
Yongcheng PanYing JiangJuan WanZhengmao HuHong JiangLu ShenBeisha TangYun TianQiong LiuPublished in: Cell & bioscience (2023)
Our study provided the first in vivo evidence linking GGC repeat expansions within NOTCH2NLC to cardiac abnormalities and highlighted the contribution of mitochondrial dysfunction in the development of cardiac abnormalities.