Impact of pigment dispersion on trabecular meshwork cells.

Chao WangYalong DangRalitsa T LoewenSusannah WaxmanPriyal ShahXiaobo XiaNils A Loewen

Published in: Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie (2019)

Exposure of TM cells to pigment dispersion resulted in reduced phagocytosis and migration, as well as increased stress fiber formation and cell contraction. The Rho signaling pathway played a central and early role, suggesting that its inhibitors could be used as a specific intervention in treatment of pigmentary glaucoma.

Keyphrases

induced apoptosis
signaling pathway
cell cycle arrest
epithelial mesenchymal transition
stem cells
smooth muscle
bone mineral density
bone marrow
body composition
cell proliferation
combination therapy