Evaluating synergistic effects of metformin and simvastatin on ovarian cancer cells.
Sara MikhaelAbdallah KurdiNathalie Khoueiry-ZgheibRoula TahtouhRihab R NasrGeorge HilalPublished in: PloS one (2024)
Our data strongly supports the presence of synergy between MTF and SIM in OC cells. The combination's effect is associated with the dysregulation of genes in the key regulators AMPK and mTOR alongside other interconnected pathways.
Keyphrases
- induced apoptosis
- cell cycle arrest
- electronic health record
- genome wide
- cell proliferation
- skeletal muscle
- transcription factor
- big data
- endoplasmic reticulum stress
- signaling pathway
- gene expression
- machine learning
- bioinformatics analysis
- drug delivery
- genome wide identification
- data analysis
- genome wide analysis