Microbiota metabolized Bile Acids accelerate Gastroesophageal Adenocarcinoma via FXR inhibition.

Theresa BaumeisterAndrea Proaño-VascoAmira MetwalyKarin KleigreweAlexander KuznetsovLinus SchömigMartin BorgmannMohammed KhiatAkanksha AnandKatrin BöttcherDirk HallerAndreas DunkelVeronika SomozaSinah ReiterChen MengRobert ThimmeRoland M SchmidDeepa T PatilElke BurgermeisterYiming HuangYiwei SunHarris H WangTimothy C WangJulian A AbramsMichael Quante

Published in: bioRxiv : the preprint server for biology (2024)

If its inhibition is linked to disease progression and its activation to cancer prevention, exploring the potential of FXR as a therapeutic target has great clinical relevance in GEAC context.

Keyphrases

papillary thyroid
squamous cell carcinoma
young adults
risk assessment
lymph node metastasis
climate change