The importance of molecular classification in clinical practice of endometrial carcinomas: how to apply it and difficulties in application.

Classification of endometrial carcinomas based on solely histological features is not sufficient for prognostic and therapeutic guidance of patients. The presence of endometrial carcinomas in which the histological type cannot also be determined clearly and the poor reproducibility of the histological typing lead difficulties on the management of these patients. Molecular classification is very promising due to its high reproducibility and good correlation with clinical outcome of the endometrial carcinoma. Within the scope of "The Cancer Genome Atlas Project", endometrial carcinomas were divided into four different genomic subtypes, and molecular classification models for endometrial carcinomas were developed based on these molecular subcategories. The prognostic differences of these molecular subgroups and their guiding role for adjuvant therapy have been clearly demonstrated in studies. In this article, the importance of molecular classification for endometrial carcinoma is discussed with different aspects and its use in clinical practice is reviewed.