Germline polymorphisms associated with impaired survival outcomes and somatic tumor alterations in advanced prostate cancer.

William S ChenEric L FengRahul AggarwalAdam FoyeTomasz M BeerJoshi J AlumkalMartin GleaveKim N ChiRobert E ReiterMatthew B RettigChristopher P EvansEric J SmallNima SharifiShuang G Zhao

Published in: Prostate cancer and prostatic diseases (2019)

This study presents a comprehensive assessment of germline variants in androgen metabolism genes and highlights HSD3B1 polymorphisms as prognostic of OS after ADT and associated with an aggressive gene expression tumor profile in mCRPC.

Keyphrases

prostate cancer
gene expression
copy number
dna repair
dna methylation
genome wide
radical prostatectomy