Androgen-repressed lncRNA LINC01126 drives castration-resistant prostate cancer by regulating the switch between O-GlcNAcylation and phosphorylation of androgen receptor.

Yi CaiMinfeng ChenYuchen GongGuyu TangZhiwei ShuJiaxian ChenHengfeng ZhouYao HeZhi LongYu Gan

Published in: Clinical and translational medicine (2024)

Our research expands the functions of AR-regulated lncRNA in sustaining androgen-independent AR activity and promoting CRPC progression and reveals that LINC01126 may be a new therapeutic target for PCa.

Keyphrases

long non coding rna
long noncoding rna
cell proliferation
transcription factor
protein kinase