Biomarkers of bone disease in persons with haemophilia.

Galen M GoldscheitterMichael RechtPaul SochackiMarilyn J Manco-Johnson Jason A Taylor

Published in: Haemophilia : the official journal of the World Federation of Hemophilia (2020)

In PwH, markers of bone metabolism and circulating cytokine levels are abnormal. Recent factor use reverses many of these differences suggesting FVIII replacement ameliorates this pathology. This study suggests bone disease present in PwH is intrinsic to FVIII deficiency.

Keyphrases

bone mineral density
soft tissue
bone loss
bone regeneration
postmenopausal women
mouse model