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Increased concentrations of bioactive adrenomedullin subsequently to angiotensin-receptor/neprilysin-inhibitor treatment in chronic systolic heart failure.

Henrike ArfstenGeorg GoliaschPhilipp E BartkoPhilipp E BartkoGeorg SpinkaAnna ChoJohannes NovakHelmuth HaslacherGuido StrunkJoachim StruckMartin HülsmannNoemi Pavo
Published in: British journal of clinical pharmacology (2020)
The significant increase of MR-proADM and bio-ADM together with an elevated bioADM/MR-proADM ratio suggest both enhanced formation and reduced breakdown of bioactive ADM following the initiation of ARNi. Activation of the ADM-axis represents a so far unrecognized effect of ARNi.
Keyphrases
  • heart failure
  • left ventricular
  • contrast enhanced
  • blood pressure
  • magnetic resonance
  • magnetic resonance imaging
  • cardiac resynchronization therapy
  • computed tomography