Premenopausal bilateral oophorectomy and brain white matter brain integrity in later-life.
Michelle M MielkeRyan D FrankLuke R ChristensonRobert I ReidJulie A FieldsZhenya E KnyazhanskayaFirat KaraPrashanthi VemuriWalter A RoccaKejal KantarciPublished in: Alzheimer's & dementia : the journal of the Alzheimer's Association (2024)
Females with premenopausal bilateral oophorectomy (PBO) < 40 years had lower FA versus referents. Females with PBO < 40 years had higher MD in many regions versus referents. Adjusting for estrogen replacement therapy use did not attenuate results. Females with PBO 45-49 years also had some white matter changes versus referents.