Sexual dimorphism in adipose tissue mitochondrial function and metabolic flexibility in obesity.
Amanda D V MacCannellT Simon FutersAnna WhiteheadAmy MoranKlaus K WitteLee D RobertsPublished in: International journal of obesity (2005) (2021)
We show that sexual dimorphism of weight gain is reflected in mitochondrial respiration analysis. Female mice have increased metabolic flexibility to adapt to changes in energy intake by regulating energy expenditure through increased complex II and maximal mitochondrial respiration within BAT when HFD challenged and increased proton leak in sWAT mitochondria.
Keyphrases
- weight gain
- body mass index
- adipose tissue
- birth weight
- insulin resistance
- oxidative stress
- high fat diet induced
- high fat diet
- weight loss
- mental health
- metabolic syndrome
- type diabetes
- heart rate
- cell death
- resistance training
- blood pressure
- body composition
- physical activity
- high intensity
- reactive oxygen species
- endoplasmic reticulum