Effects of motor cortical and peripheral axonal hyperexcitability on survival in amyotrophic lateral sclerosis.
Ryo OtaniKazumoto ShibuyaYo-Ichi SuzukiTomoki SuichiMarie MorookaYuya AotsukaMoeko OgushiSatoshi KuwabaraPublished in: Journal of neurology, neurosurgery, and psychiatry (2024)
In patients with ALS, both motor cortical and peripheral hyperexcitability independently affected survival time, with peripheral hyperexcitability having a greater impact on shorter survival. The modulation of neuronal/axonal excitability is a potential therapeutic target for ALS.