Neprilysin Inhibition Increases Glucagon Levels in Humans and Mice With Potential Effects on Amino Acid Metabolism.

Sasha A S KjeldsenLasse H HansenNathalie EsserSteve MongovinMarie Winther-SørensenKatrine D GalsgaardJenna E HuntHannelouise KissowFrederik R CeutzDijana TerzicPeter D MarkPeter PlomgaardJens P GoetzeGijs H GoossensEllen E BlaakCarolyn F DeaconMette M RosenkildeSakeneh ZraikaJens J HolstNicolai J Wewer Albrechtsen

Published in: Journal of the Endocrine Society (2021)

NEP cleaves glucagon, and inhibitors of NEP result in hyperglucagonemia and may increase postprandial AA catabolism without affecting glycemia.

Keyphrases

amino acid
high fat diet induced
blood glucose
metabolic syndrome