Chemical augmentation of mitochondrial electron transport chains tunes T cell activation threshold in tumors.
Daisuke MuraokaDaisuk MuraokaNaohisa OgoYudai SonodaKiyoshi YasuiHiroyuki YamaguchiHideo YagitaHiroshi MukaeAkira AsaiHiroaki IkedaPublished in: Journal for immunotherapy of cancer (2022)
These data suggest that tuning the T cell activation threshold by chemical activation of mitochondrial ETC is a new strategy for improving therapeutic efficacy through the activation of low-avidity tumor-specific T cells.