STK11 Inactivation Predicts Rapid Recurrence in Inoperable Early-Stage Non-Small-Cell Lung Cancer.
Rohan R KatipallyLiam F SpurrStanley I GutiontovWilliam Tyler TurchanPhilip ConnellAditya JulooriRenuka MalikMichael Sargent BinkleyAlice L JiangSherin Juliet RouhaniCarolina Soto ChervinPankhuri WanjariJeremy P SegalVictor NgBilly W LooDaniel R GomezChristine M BestvinaEverett E VokesMark K FergusonJessica S DoningtonMaximillian DiehnSean P PitrodaPublished in: JCO precision oncology (2023)
inactivation was associated with poor oncologic outcomes after RT and demonstrated a novel association with clinical hypoxia, which may underlie its correlation with medical inoperability. Further validation in larger cohorts and investigation of effective adjuvant systemic therapies may be warranted.