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SARS-CoV-2 transmission routes from genetic data: A Danish case study

Andreas BluhmMatthias ChristandlFulvio GesmundoFrederik Ravn KlausenLaura MančinskaVincent SteffanDaniel Stilck FrançaAlbert H Werner
Published in: PloS one (2020)
Employing phylogenetic methods on Danish genome sequences of SARS-CoV-2, we exemplify how genetic data can be used to trace the introduction of a virus to a country. This provides alternative means for verifying existing assumptions. For example, our analysis supports the hypothesis that the virus was brought to Denmark by skiers returning from Ischgl. On the other hand, we identify transmission routes which suggest that Denmark was part of a network of countries among which the virus was being transmitted. This challenges the common narrative that Denmark only got infected from abroad. Our analysis concerning the ratio of haplotypes does not indicate that the major haplotypes appearing in Denmark have a different degree of virality.
Keyphrases
  • sars cov
  • genome wide
  • electronic health record
  • big data
  • gene expression
  • disease virus