Performance of clinical signs and symptoms, rapid and reference laboratory diagnostic tests for diagnosis of human African trypanosomiasis by passive screening in Guinea: a prospective diagnostic accuracy study.
Oumou CamaraMamadou CamaraLaura Cristina FalzonHamidou IlboudoJacques KaboréCharlie Franck Alfred CompaoréEric Maurice FèvrePhilippe BüscherBruno BuchetonVeerle LejonPublished in: Infectious diseases of poverty (2023)
Presence of swollen lymph nodes, important weight loss, severe itching or motor disorders are simple but accurate clinical criteria for HAT referral in HAT endemic areas in Guinea. Diagnostic performances of HAT Sero-K-Set and SD Bioline HAT are sufficient for referring positives to microscopy. Trypanolysis on DBS may discriminate HAT patients from false RDT positives. Trial registration The trial was registered under NCT03356665 in clinicaltrials.gov (November 29, 2017, retrospectively registered https://clinicaltrials.gov/ct2/show/NCT03356665 ).
Keyphrases
- lymph node
- weight loss
- end stage renal disease
- phase iii
- study protocol
- clinical trial
- ejection fraction
- endothelial cells
- high resolution
- newly diagnosed
- chronic kidney disease
- phase ii
- primary care
- peritoneal dialysis
- computed tomography
- prognostic factors
- deep brain stimulation
- high throughput
- depressive symptoms
- early stage
- mass spectrometry
- roux en y gastric bypass
- body mass index
- dual energy
- high speed
- gastric bypass
- single cell
- sleep quality
- placebo controlled