Constitutive activity of the dopamine receptor D5R, highly expressed in CA1 hippocampal neurons, selectively reduces Ca V 3.2 and Ca V 3.3 currents.

Emilio Román MustafáClara Inés McCarthyAndrea Estefanía PortalesSantiago Cordisco GonzalezSilvia Susana RodríguezJesica Raingo

Published in: British journal of pharmacology (2022)

3.2-3 are sensitive to D5R constitutive activity. Manipulation of D5R constitutive activity could be a valuable strategy to control neuronal excitability, especially in exacerbated conditions such as epilepsy.

Keyphrases

spinal cord
protein kinase
uric acid
blood brain barrier
binding protein
prefrontal cortex