Endemic coronavirus infections are associated with strong homotypic immunity in a US cohort of children from birth to 4 years.
Ardythe L MorrowDaniel C PayneShannon C ConreyMeredith L McMorrowMonica M McNealLiang NiuAllison R BurrellElizabeth P SchlaudeckerClaire MattisonRachel M BurkeEmily DeFrancoZheyi TeohJens WrammertLydia J AthertonNatalie J ThornburgMary A StaatPublished in: Journal of the Pediatric Infectious Diseases Society (2024)
Natural coronavirus infections were common and resulted in strong homotypic immunity but not heterotypic immunity against other coronaviruses, including SARS-CoV-2. Endemic coronavirus and SARS-CoV-2 infections in this US cohort were typically asymptomatic or mild.