ITCH-dependent proteasomal degradation of c-FLIP induced by the anti-HER3 antibody 9F7-F11 promotes DR5/caspase 8-mediated apoptosis of tumor cells.

Christophe Le ClorennecYassamine LazrekOlivier DubreuilCarla SampaioChristel LarbouretRomain LanotteMarie-Alix PoulJean-Marc BarretJean-François ProstAndré PèlegrinThierry Chardès

Published in: Cell communication and signaling : CCS (2019)

The allosteric non-neuregulin competing modulator 9F7-F11, sensitizes tumor cells to DR5/caspase-8-mediated apoptosis through ITCH-dependent downregulation of c-FLIP.

Keyphrases

induced apoptosis
cell death
editorial comment
signaling pathway
small molecule
endoplasmic reticulum stress
cell proliferation
atopic dermatitis